Studies on Griseofulvin. 1. Serum Griseofulvin Levels after Oral Administration. (Studies on Antifungal Agents. VI. Report)

Hepatocareinogenicity of Griseofulvin following Parenteral Administration to Infant Mice1

Random-bred infant Swiss mice were injected subcutaneously with suspensions of griseofulvin in tricaprylin according to various dosage schedules. Doses of griseofulvin in excess of 0.25 mg on Day 1 of life produced acute toxicity. Following a total dosage of 3.0 mg in infant mice. 0.5, 0.5, 1.0, and 1.0 mg at ages of 1, 7, 14, and 21 days, respectively, a high incidence of hepatomata, in 44% of...

Oral griseofulvin: a cocarcinogenic agent to methylcholanthrene induced cutaneous tumors.

Since certain antitumor drugs also arrest mitosis in metaphase, an attempt was made to determine the effect of oral griseofulvin on methylcholanthrene-induced cutaneous tumors in mice. Contrary to expectations, mice on large doses (1000-1500 mg/kg) of griseofulvin subjected to methylcholanthrene applications had a shorter tumor lag period and developed more and larger tumors than did mice not r...

Cardiovascular effects of griseofulvin.

The intravenous administration of griseofulvin in doses of 3.0 mg/kg to 32 anesthetized open-chest dogs produced marked increments (43%) in isometric systolic force measured by a strain gauge. These changes were accompanied by an increase (22%) in heart rate and a decrease (25%) in blood pressure. The effect was unaltered by clamping the blood supply to and from the adrenal glands or by previou...

The chemistry of griseofulvin.

Protective Action of Antioxidants on Hepatic Damage Induced by Griseofulvin

Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis were observed. Griseofulvin (Gris) develops an experimental EPP with hepatic manifestations in mice such as PROTO IX accumulation followed by cell...